Physiolibrary.Media.Blood

Blood

Information

Adding new substance to blood model:


- add to Blood.substanceNames

- modify {plasma/formedElements}{MassFraction+SpecificAmountOfParticles}

- modify functions: Blood.specificEnthalpies_Tpv

- modify model: Blood.ArterialComposition, run it and resuled X set as ArterialDefault (and from VenousComposition -> VenousDefault)

- modify model: Blood.ChemicalSolution,

Extends from Media.Interfaces.PartialMedium.

Package Content

Name Description
ArterialDefault={0.47397342,0.2602675,0.00024730066,0.00060022215,0.00028510197,4.0067286e-11,0.13012053,0.0006506026,0.0006506026,0.023240043,0.0148344375,7.7006625e-06,0.0005979338,0.00058174727,4.9633483e-05,0.00021128391,0.00026331126,0.0005255277,2.637139e-06,0.0016869484,8.2860926e-05,6.699073e-05,0.0015625204,0.0018235744,0.0008487089,2.1192053e-11,1.2715232e-10,1.0567206e-12,3.675887e-10,3.6916557e-11,5.978278e-11,4.2172186e-08,4.2172186e-09,5.298013e-15,1.0596027e-11,7.12053e-15,6.301733e-11,0.025162973,0.061655864} Default mass fraction in arterial blood
VenousDefault={0.47057825,0.26366264,0.0001659035,0.00065897073,0.00033050895,4.0067286e-11,0.13012053,0.0006506026,0.0006506026,0.023240043,0.0148344375,7.7006625e-06,0.0005979338,0.00058174727,4.9633483e-05,0.00021128391,0.00026331126,0.0005255277,2.637139e-06,0.0016869484,8.2860926e-05,6.699073e-05,0.0015625204,0.0017914142,0.00088086916,2.1192053e-11,1.2715232e-10,1.0567206e-12,3.675887e-10,3.6916557e-11,5.978278e-11,4.2172186e-08,4.2172186e-09,5.298013e-15,1.0596027e-11,7.12053e-15,6.301733e-11,0.028531536,0.05826454} Default mass fraction in venous blood
CDefault={1e-20,1e-20,1e-06}  
Physiolibrary.Media.Blood.plasmaMassFraction plasmaMassFraction Blood plasmacrit [kg/kg]
Physiolibrary.Media.Blood.plasmaSpecificAmountOfParticles plasmaSpecificAmountOfParticles Amount of free particles in 1 kg of blood plasma
Physiolibrary.Media.Blood.formedElementsMassFraction formedElementsMassFraction Blood hematocrit [kg/kg]
Physiolibrary.Media.Blood.formedElementsSpecificAmountOfParticles formedElementsSpecificAmountOfParticles Amount of free particles in 1 kg of blood formed elements
Physiolibrary.Media.Blood.ArterialComposition ArterialComposition To set mass fractions in blood
Physiolibrary.Media.Blood.VenousComposition VenousComposition To set mass fractions in blood
Physiolibrary.Media.Blood.SubstancesPort SubstancesPort Blood chemical substances interface
Physiolibrary.Media.Blood.ThermodynamicState ThermodynamicState A selection of variables that uniquely defines the thermodynamic state
Physiolibrary.Media.Blood.stateOfMatter stateOfMatter Substances model to translate data into substance properties
Physiolibrary.Media.Blood.ChemicalSolution ChemicalSolution Free chemical substances
Physiolibrary.Media.Blood.BloodGases BloodGases Hydrogen Ion, Carbon Dioxide, and Oxygen in the Blood
Physiolibrary.Media.Blood.BaseProperties BaseProperties Base properties of medium
Physiolibrary.Media.Blood.specificEnthalpies_Tpv specificEnthalpies_Tpv Specific enthalpies of blood substances
Physiolibrary.Media.Blood.specificEnthalpy specificEnthalpy Return specific enthalpy
Physiolibrary.Media.Blood.hemoglobinDissociationCurve hemoglobinDissociationCurve Hemoglobin dissociation curve as saturation of O2 and CO2 on hemoglobin (excluded methemoglobin)
Physiolibrary.Media.Blood.hemoglobinDissociationCurve_der hemoglobinDissociationCurve_der Derivative of Hemoglobin dissociation curve as saturation of O2 and CO2 on hemoglobin (excluded methemoglobin)
Physiolibrary.Media.Blood.setState_pTX setState_pTX Thermodynamic state
Physiolibrary.Media.Blood.setState_phX setState_phX Thermodynamic state
Physiolibrary.Media.Blood.density density Density
Physiolibrary.Media.Blood.plasmaDensity plasmaDensity Density of blood plasma
Physiolibrary.Media.Blood.specificHeatCapacityCp specificHeatCapacityCp Specific heat capacityReturn specific heat capacity at constant pressure
Physiolibrary.Media.Blood.temperature temperature Temperature
Physiolibrary.Media.Blood.pressure pressure Pressure
Physiolibrary.Media.Blood.tO2 tO2 Total oxygen in blood
Physiolibrary.Media.Blood.sO2 sO2 Oxygen saturation on effective hemoglobin
Physiolibrary.Media.Blood.tCO2 tCO2 Total carbon dioxide in blood
Physiolibrary.Media.Blood.tCO tCO Total carbon monoxide in blood
Physiolibrary.Media.Blood.tHb tHb Total hemoglobine in blood
Physiolibrary.Media.Blood.FMetHb FMetHb Methemoglobine fraction
Physiolibrary.Media.Blood.FHbF FHbF Foetalhemoglobine fraction
Physiolibrary.Media.Blood.ctHb_ery ctHb_ery Total hemoglobine in erythrocytes
Physiolibrary.Media.Blood.tAlb tAlb Total albumine in blood plasma
Physiolibrary.Media.Blood.tGlb tGlb Total globulin in blood plasma [g/L]
Physiolibrary.Media.Blood.tPO4 tPO4 Total anorganic phosphates in blood plasma
Physiolibrary.Media.Blood.cDPG cDPG Total diphosphoglycerate in erythrocytes
Physiolibrary.Media.Blood.SID SID Strong ion difference of blood
Physiolibrary.Media.Blood.glucose glucose Total glucose in blood plasma
Physiolibrary.Media.Blood.lactate lactate Total lactate in blood plasma
Physiolibrary.Media.Blood.urea urea Total urea in blood plasma
Physiolibrary.Media.Blood.aminoAcids aminoAcids Total amino acids in blood plasma
Physiolibrary.Media.Blood.lipids lipids Total faty acids in blood plasma
Physiolibrary.Media.Blood.ketoAcids ketoAcids Total ketoacids in blood plasma
Physiolibrary.Media.Blood.epinephrine epinephrine Epinephrine in blood plasma
Physiolibrary.Media.Blood.norepinephrine norepinephrine Norepinephrine in blood plasma
Physiolibrary.Media.Blood.vasopressin vasopressin Vasopressin in blood plasma
Physiolibrary.Media.Blood.insulin insulin Insulin in blood plasma
Physiolibrary.Media.Blood.glucagon glucagon Glucagon in blood plasma
Physiolibrary.Media.Blood.thyrotropin thyrotropin Thyrotropin in blood plasma
Physiolibrary.Media.Blood.thyroxine thyroxine Thyroxine in blood plasma
Physiolibrary.Media.Blood.leptin leptin Leptin in blood plasma
Physiolibrary.Media.Blood.desglymidodrine desglymidodrine Desglymidodrine in blood plasma
Physiolibrary.Media.Blood.angiotensin2 angiotensin2 Angiotensin2 in blood plasma
Physiolibrary.Media.Blood.alphaBlockers alphaBlockers Alpha blockers effect
Physiolibrary.Media.Blood.betaBlockers betaBlockers Beta blockers effect
Physiolibrary.Media.Blood.anesthesiaVascularConductance anesthesiaVascularConductance Anesthesia vascular conductance effect
Physiolibrary.Media.Blood.aldosterone aldosterone Aldosterone in blood plasma
Physiolibrary.Media.Blood.renin renin Renin PRA in blood plasma
Physiolibrary.Media.Blood.plasmacrit plasmacrit Blood plasmacrit [mL/mL]
Physiolibrary.Media.Blood.hematocrit hematocrit Blood hematocrit [mL/mL]
Physiolibrary.Media.Blood.formedElementsDensity formedElementsDensity Density of blood formed elements (erythrocytes, leukocytes and thrombocytes)
Physiolibrary.Media.Blood.formedElementsMassFractionWithoutOther formedElementsMassFractionWithoutOther Blood hematocrit without unknown substances in formed elements [kg/kg]
Physiolibrary.Media.Blood.plasmaMassFractionWithoutOther plasmaMassFractionWithoutOther Blood plasmacrit without unknown substances in blood plasma [kg/kg]
Inherited
Physiolibrary.Media.Interfaces.PartialMedium.i i Find index of substance
Physiolibrary.Media.Interfaces.PartialMedium.j j Find index of extra property
SubstanceFlowNominal=ArterialDefault ./ Constants.TimeScale Nominal of substance flow
SpecificEnthalpyNominal=-1E6 Nominal of specific enthalpy
Physiolibrary.Media.Interfaces.PartialMedium.temperatureError temperatureError To find u as temperature, where temperatureError(u,p,X,h)->0
Physiolibrary.Media.Interfaces.PartialMedium.GetMolality GetMolality  
Physiolibrary.Media.Interfaces.PartialMedium.GetMassConcentration GetMassConcentration  
Physiolibrary.Media.Interfaces.PartialMedium.GetFraction GetFraction  
Physiolibrary.Media.Interfaces.PartialMedium.GetActivity GetActivity  
Physiolibrary.Media.Interfaces.PartialMedium.GetDensity GetDensity  
Physiolibrary.Media.Interfaces.PartialMedium.GetExtraProperty GetExtraProperty  
Physiolibrary.Media.Interfaces.PartialMedium.GetConcentration GetConcentration  
ThermoStates=Modelica.Media.Interfaces.Choices.IndependentVariables.phX Enumeration type for independent variables
mediumName="Blood" Name of the medium
substanceNames={"H2O_P","H2O_E","O2","CO2_P","CO2_E","CO","eHb","MetHb","HbF","Alb","Glb","PO4","DPG","Glucose","Lactate","Urea","AminoAcids","Lipids","KetoAcids","Na_P","K_P","Na_E","K_E","Cl_P","Cl_E","Epinephrine","Norepinephrine","Vasopressin","Insulin","Glucagon","Thyrotropin","Thyroxine","Leptin","Desglymidodrine","Angiotensin2","Renin","Aldosterone","Other_P","Other_E"} Names of the mixture substances. Set substanceNames={mediumName} if only one substance.
extraPropertiesNames={"AlphaBlockers","BetaBlockers","AnesthesiaVascularConductance"} Names of the additional (extra) transported properties. Set extraPropertiesNames=fill("",0) if unused
singleState=true = true, if u and d are not a function of pressure
reducedX=false = true if medium contains the equation sum(X) = 1.0; set reducedX=true if only one substance (see docu for details)
fixedX=false = true if medium contains the equation X = reference_X
reference_p=101325 Reference pressure of Medium: default 1 atmosphere
reference_T=310.15 Reference temperature of Medium: default 25 deg Celsius
reference_X=ArterialDefault Default mass fractions of medium
p_default=101325 Default value for pressure of medium (for initialization)
T_default=Modelica.Units.Conversions.from_degC(20) Default value for temperature of medium (for initialization)
h_default=specificEnthalpy_pTX(p_default, T_default, X_default) Default value for specific enthalpy of medium (for initialization)
X_default=reference_X Default value for mass fractions of medium (for initialization)
C_default=CDefault Default value for trace substances of medium (for initialization)
nS=size(substanceNames, 1) Number of substances
nX=nS Number of mass fractions
nXi=if fixedX then 0 else if reducedX then nS - 1 else nS Number of structurally independent mass fractions (see docu for details)
nC=size(extraPropertiesNames, 1) Number of extra (outside of standard mass-balance) transported properties
C_nominal=1.0e-6*ones(nC) Default for the nominal values for the extra properties
Modelica.Media.Interfaces.PartialMedium.FluidConstants FluidConstants Critical, triple, molecular and other standard data of fluid
Modelica.Media.Interfaces.PartialMedium.setState_psX setState_psX Return thermodynamic state as function of p, s and composition X or Xi
Modelica.Media.Interfaces.PartialMedium.setState_dTX setState_dTX Return thermodynamic state as function of d, T and composition X or Xi
Modelica.Media.Interfaces.PartialMedium.setSmoothState setSmoothState Return thermodynamic state so that it smoothly approximates: if x > 0 then state_a else state_b
Modelica.Media.Interfaces.PartialMedium.dynamicViscosity dynamicViscosity Return dynamic viscosity
Modelica.Media.Interfaces.PartialMedium.thermalConductivity thermalConductivity Return thermal conductivity
Modelica.Media.Interfaces.PartialMedium.prandtlNumber prandtlNumber Return the Prandtl number
Modelica.Media.Interfaces.PartialMedium.specificInternalEnergy specificInternalEnergy Return specific internal energy
Modelica.Media.Interfaces.PartialMedium.specificEntropy specificEntropy Return specific entropy
Modelica.Media.Interfaces.PartialMedium.specificGibbsEnergy specificGibbsEnergy Return specific Gibbs energy
Modelica.Media.Interfaces.PartialMedium.specificHelmholtzEnergy specificHelmholtzEnergy Return specific Helmholtz energy
Modelica.Media.Interfaces.PartialMedium.heatCapacity_cp heatCapacity_cp Alias for deprecated name
Modelica.Media.Interfaces.PartialMedium.specificHeatCapacityCv specificHeatCapacityCv Return specific heat capacity at constant volume
Modelica.Media.Interfaces.PartialMedium.heatCapacity_cv heatCapacity_cv Alias for deprecated name
Modelica.Media.Interfaces.PartialMedium.isentropicExponent isentropicExponent Return isentropic exponent
Modelica.Media.Interfaces.PartialMedium.isentropicEnthalpy isentropicEnthalpy Return isentropic enthalpy
Modelica.Media.Interfaces.PartialMedium.velocityOfSound velocityOfSound Return velocity of sound
Modelica.Media.Interfaces.PartialMedium.isobaricExpansionCoefficient isobaricExpansionCoefficient Return overall the isobaric expansion coefficient beta
Modelica.Media.Interfaces.PartialMedium.beta beta Alias for isobaricExpansionCoefficient for user convenience
Modelica.Media.Interfaces.PartialMedium.isothermalCompressibility isothermalCompressibility Return overall the isothermal compressibility factor
Modelica.Media.Interfaces.PartialMedium.kappa kappa Alias of isothermalCompressibility for user convenience
Modelica.Media.Interfaces.PartialMedium.density_derp_h density_derp_h Return density derivative w.r.t. pressure at const specific enthalpy
Modelica.Media.Interfaces.PartialMedium.density_derh_p density_derh_p Return density derivative w.r.t. specific enthalpy at constant pressure
Modelica.Media.Interfaces.PartialMedium.density_derp_T density_derp_T Return density derivative w.r.t. pressure at const temperature
Modelica.Media.Interfaces.PartialMedium.density_derT_p density_derT_p Return density derivative w.r.t. temperature at constant pressure
Modelica.Media.Interfaces.PartialMedium.density_derX density_derX Return density derivative w.r.t. mass fraction
Modelica.Media.Interfaces.PartialMedium.molarMass molarMass Return the molar mass of the medium
Modelica.Media.Interfaces.PartialMedium.specificEnthalpy_pTX specificEnthalpy_pTX Return specific enthalpy from p, T, and X or Xi
Modelica.Media.Interfaces.PartialMedium.specificEntropy_pTX specificEntropy_pTX Return specific enthalpy from p, T, and X or Xi
Modelica.Media.Interfaces.PartialMedium.density_pTX density_pTX Return density from p, T, and X or Xi
Modelica.Media.Interfaces.PartialMedium.temperature_phX temperature_phX Return temperature from p, h, and X or Xi
Modelica.Media.Interfaces.PartialMedium.density_phX density_phX Return density from p, h, and X or Xi
Modelica.Media.Interfaces.PartialMedium.temperature_psX temperature_psX Return temperature from p,s, and X or Xi
Modelica.Media.Interfaces.PartialMedium.density_psX density_psX Return density from p, s, and X or Xi
Modelica.Media.Interfaces.PartialMedium.specificEnthalpy_psX specificEnthalpy_psX Return specific enthalpy from p, s, and X or Xi
Modelica.Media.Interfaces.PartialMedium.MassFlowRate MassFlowRate Type for mass flow rate with medium specific attributes
Modelica.Media.Interfaces.Types.AbsolutePressure AbsolutePressure Type for absolute pressure with medium specific attributes
Modelica.Media.Interfaces.Types.Density Density Type for density with medium specific attributes
Modelica.Media.Interfaces.Types.DynamicViscosity DynamicViscosity Type for dynamic viscosity with medium specific attributes
Modelica.Media.Interfaces.Types.EnthalpyFlowRate EnthalpyFlowRate Type for enthalpy flow rate with medium specific attributes
Modelica.Media.Interfaces.Types.MassFraction MassFraction Type for mass fraction with medium specific attributes
Modelica.Media.Interfaces.Types.MoleFraction MoleFraction Type for mole fraction with medium specific attributes
Modelica.Media.Interfaces.Types.MolarMass MolarMass Type for molar mass with medium specific attributes
Modelica.Media.Interfaces.Types.MolarVolume MolarVolume Type for molar volume with medium specific attributes
Modelica.Media.Interfaces.Types.IsentropicExponent IsentropicExponent Type for isentropic exponent with medium specific attributes
Modelica.Media.Interfaces.Types.SpecificEnergy SpecificEnergy Type for specific energy with medium specific attributes
Modelica.Media.Interfaces.Types.SpecificInternalEnergy SpecificInternalEnergy Type for specific internal energy with medium specific attributes
Modelica.Media.Interfaces.Types.SpecificEnthalpy SpecificEnthalpy Type for specific enthalpy with medium specific attributes
Modelica.Media.Interfaces.Types.SpecificEntropy SpecificEntropy Type for specific entropy with medium specific attributes
Modelica.Media.Interfaces.Types.SpecificHeatCapacity SpecificHeatCapacity Type for specific heat capacity with medium specific attributes
Modelica.Media.Interfaces.Types.SurfaceTension SurfaceTension Type for surface tension with medium specific attributes
Modelica.Media.Interfaces.Types.Temperature Temperature Type for temperature with medium specific attributes
Modelica.Media.Interfaces.Types.ThermalConductivity ThermalConductivity Type for thermal conductivity with medium specific attributes
Modelica.Media.Interfaces.Types.PrandtlNumber PrandtlNumber Type for Prandtl number with medium specific attributes
Modelica.Media.Interfaces.Types.VelocityOfSound VelocityOfSound Type for velocity of sound with medium specific attributes
Modelica.Media.Interfaces.Types.ExtraProperty ExtraProperty Type for unspecified, mass-specific property transported by flow
Modelica.Media.Interfaces.Types.CumulativeExtraProperty CumulativeExtraProperty Type for conserved integral of unspecified, mass specific property
Modelica.Media.Interfaces.Types.ExtraPropertyFlowRate ExtraPropertyFlowRate Type for flow rate of unspecified, mass-specific property
Modelica.Media.Interfaces.Types.IsobaricExpansionCoefficient IsobaricExpansionCoefficient Type for isobaric expansion coefficient with medium specific attributes
Modelica.Media.Interfaces.Types.DipoleMoment DipoleMoment Type for dipole moment with medium specific attributes
Modelica.Media.Interfaces.Types.DerDensityByPressure DerDensityByPressure Type for partial derivative of density with respect to pressure with medium specific attributes
Modelica.Media.Interfaces.Types.DerDensityByEnthalpy DerDensityByEnthalpy Type for partial derivative of density with respect to enthalpy with medium specific attributes
Modelica.Media.Interfaces.Types.DerEnthalpyByPressure DerEnthalpyByPressure Type for partial derivative of enthalpy with respect to pressure with medium specific attributes
Modelica.Media.Interfaces.Types.DerDensityByTemperature DerDensityByTemperature Type for partial derivative of density with respect to temperature with medium specific attributes
Modelica.Media.Interfaces.Types.DerTemperatureByPressure DerTemperatureByPressure Type for partial derivative of temperature with respect to pressure with medium specific attributes
Modelica.Media.Interfaces.Types.SaturationProperties SaturationProperties Saturation properties of two phase medium
Modelica.Media.Interfaces.Types.FluidLimits FluidLimits Validity limits for fluid model
Modelica.Media.Interfaces.Types.FixedPhase FixedPhase Phase of the fluid: 1 for 1-phase, 2 for two-phase, 0 for not known, e.g., interactive use
Modelica.Media.Interfaces.Types.Basic Basic The most basic version of a record used in several degrees of detail
Modelica.Media.Interfaces.Types.IdealGas IdealGas The ideal gas version of a record used in several degrees of detail
Modelica.Media.Interfaces.Types.TwoPhase TwoPhase The two phase fluid version of a record used in several degrees of detail

Physiolibrary.Media.Blood.plasmaMassFraction

Blood plasmacrit [kg/kg]

Information

Mass of blood plasma per mass of blood.

Extends from GetFraction.

Inputs

NameDescription
state 

Outputs

NameDescription
F[1]

Physiolibrary.Media.Blood.plasmaSpecificAmountOfParticles

Amount of free particles in 1 kg of blood plasma

Information

Amount of particles in blood plasma per mass of blood plasma.

Extends from GetMolality.

Inputs

NameDescription
state 
T[K]
pct[1]

Outputs

NameDescription
B[mol/kg]

Physiolibrary.Media.Blood.formedElementsMassFraction

Blood hematocrit [kg/kg]

Information

Mass of formed elements per mass of blood.

Extends from GetFraction.

Inputs

NameDescription
state 

Outputs

NameDescription
F[1]

Physiolibrary.Media.Blood.formedElementsSpecificAmountOfParticles

Amount of free particles in 1 kg of blood formed elements

Information

Amount of particles in red cells per mass of red cells.

Extends from GetMolality.

Inputs

NameDescription
state 
T[K]
hct[1]

Outputs

NameDescription
B[mol/kg]

Physiolibrary.Media.Blood.ArterialComposition

To set mass fractions in blood

Information

Calculate state of the medium from more human-like setting.

Physiolibrary.Media.Blood.VenousComposition

To set mass fractions in blood

Information

Calculate state of the medium from more human-like setting.

Extends from ArterialComposition (To set mass fractions in blood).

Parameters

NameDescription
tO2Total oxygen in blood [mol/m3]
tCO2Total carbon dioxide in blood [mol/m3]
Initialization
XE[1]
XP2[1]
PMF[1]
x_PAmount of free particles in 1 kg of blood plasma [mol/kg] [mol/kg]
x_EAmount of free particles in 1 kg of blood erythrocytes [mol/kg] [mol/kg]

Physiolibrary.Media.Blood.SubstancesPort Physiolibrary.Media.Blood.SubstancesPort

Blood chemical substances interface

Information

Electrochemical connections lead via free base substance forms. For example, the total mass fraction of carbon dioxide is represented as part of the composition of blood in fluid connector, but free dissolved carbon dioxide in blood plasma or bicarbonate in blood plasma are its electrochemical connectors proposed to model the electrochemical CO2 fluxes. Since the selected forms are precisely determined by the composition of the blood, it is not necessary to store them and pass them through the fluid connector. They are only expressed and calculated when needed.

Extends from .

Contents

NameDescription
CO2Free carbon dioxide molecule
O2Free oxygen molecule
COFree carbon monoxide moelcule
HCO3Free bicarbonate molecule
HFree protons
H2OFree water molecule (in pure water is only cca 1 mol/kg free water molecules, other cca 54.5 mols are bounded together by hydrogen bonds)
Glucose 
Lactate 
Urea 
AminoAcids 
Lipids 
KetoAcids 
Epinephrine 
Norepinephrine 
Vasopressin 
Insulin 
Glucagon 
Thyrotropin 
Thyroxine 
Leptin 
Desglymidodrine 
Angiotensin2 
Renin 
Aldosterone 

Physiolibrary.Media.Blood.ThermodynamicState Physiolibrary.Media.Blood.ThermodynamicState

A selection of variables that uniquely defines the thermodynamic state

Information

Thermodynamic state of blood is represented by pressure, temperature, base substances composition, electrical potential and ionic strengh.

Extends from Modelica.Icons.Record (Icon for records), (Minimal variable set that is available as input argument to every medium function).

Physiolibrary.Media.Blood.ChemicalSolution

Free chemical substances

Information

Chemical equilibrium is represented by expression of electrochemical potentials of base blood substances.

Extends from (Adaptor between selected free base chemical substances and medium substances).

Parameters

NameDescription
substancesfree base chemical substances
startSubstanceMasses[nS]Initial value of medium substance masses [kg]
KC_ClRate of chloride shift equilibration
KC_H2ORate of osmolarity equilibration
KC_CO2Rate of CO2 equilibration

Connectors

NameDescription
substancesfree base chemical substances
ppressure [Pa]
hspecific enthalpy [J/kg]
X[nS]mass fractions of medium substances [1]
_ielectric current from substances [A]
substanceMassFlowsFromStream[nS]flow of medium substances [kg/s]
substanceMasses[nS]mass od medium substances [kg]
massFlows[nS]mass flows trough substancesPort [kg/s]
Ttemperature [K]
enthalpyFromSubstancesenthalpy from substances [W]
velectric potential [V]

Physiolibrary.Media.Blood.BloodGases

Hydrogen Ion, Carbon Dioxide, and Oxygen in the Blood

Information

Hydrogen Ion, Carbon Dioxide, and Oxygen in the Blood (siggaard-andersen.dk)

Medsoft_2013_Matejak.pdf (creativeconnections.cz)

Parameters

NameDescription
pKa1HPO4^2- dissociation
pKa2H2PO4^- dissociation
pKa3H3PO4 dissociation
betaOxyHbBuffer value for oxygenated Hb without CO2
pIoIsoelectric pH for oxygenated Hb without CO2
pKzDCoefficient pKa for NH3+ end of deoxygenated hemoglobin chain
pKzOCoefficient pKa for NH3+ end of oxygenated hemoglobin chain
pKcD10^(pH-pKcR) is the dissociation constatnt for HbNH2 + CO2 <-> HbNHCOO- + H+
pKcO10^(pH-pKcO) is the dissociation constatnt for O2HbNH2 + CO2 <-> O2HbNHCOO- + H+
pKhD10^(pH-pKhD) is the dissociation constatnt for HbAH <-> HbA- + H+
pKhO10^(pH-pKhO) is the dissociation constatnt for O2HbAH <-> O2HbA- + H+

Physiolibrary.Media.Blood.BaseProperties Physiolibrary.Media.Blood.BaseProperties

Base properties of medium

Information

Simplification of blood:

Constant density and constant heat capacity

Extends from (Base properties (p, d, T, h, u, R_s, MM and, if applicable, X and Xi) of a medium).

Parameters

NameDescription
standardOrderComponentsIf true, and reducedX = true, the last element of X will be computed from the other ones
Advanced
preferredMediumStates= true if StateSelect.prefer shall be used for the independent property variables of the medium

Physiolibrary.Media.Blood.specificEnthalpies_Tpv

Specific enthalpies of blood substances

Information

Extends from (Specific enthalpies of medium substances).

Inputs

NameDescription
TTemperature [K]
pPressure [Pa]
vElectric potential of the substance [V]

Outputs

NameDescription
specificEnthalpy[nS]Specific enthalpies of medium substances [J/kg]

Physiolibrary.Media.Blood.specificEnthalpy Physiolibrary.Media.Blood.specificEnthalpy

Return specific enthalpy

Information

Extends from (Return specific enthalpy).

Inputs

NameDescription
stateThermodynamic state record

Outputs

NameDescription
hSpecific enthalpy [J/kg]

Physiolibrary.Media.Blood.hemoglobinDissociationCurve

Hemoglobin dissociation curve as saturation of O2 and CO2 on hemoglobin (excluded methemoglobin)

Information

Hemoglobin-Oxygen dissociation relation based on OSA (Oxygen Status Algorithm) by Siggaard Andersen.

Hydrogen Ion, Carbon Dioxide, and Oxygen in the Blood (siggaard-andersen.dk)

Inputs

NameDescription
pHacidity
pO2oxygen partial pressure
pCO2carbon dioxide partial pressure
pCOcarbon monoxide partial pressure
Ttemperature
tHbtotal hemoglobin
cDPGdiphosphoglicerate
FMetHbmethemoglobin fraction
FHbFfoethel hemoglobin fraction

Outputs

NameDescription
sO2COoxygen and carbon monoxide saturation

Physiolibrary.Media.Blood.hemoglobinDissociationCurve_der

Derivative of Hemoglobin dissociation curve as saturation of O2 and CO2 on hemoglobin (excluded methemoglobin)

Information

Hemoglobin-Oxygen dissociation relation based on OSA (Oxygen Status Algorithm) by Siggaard Andersen.

Hydrogen Ion, Carbon Dioxide, and Oxygen in the Blood (siggaard-andersen.dk)

Inputs

NameDescription
pHacidity
pO2oxygen partial pressure
pCO2carbon dioxide partial pressure
pCOcarbon monoxide partial pressure
Ttemperature
tHbtotal hemoglobin
cDPGdiphosphoglicerate
FMetHbmethemoglobin fraction
FHbFfoethel hemoglobin fraction
der_pHderivative of acidity
der_pO2derivative of oxygen partial pressure
der_pCO2derivative of carbon dioxide partial pressure
der_pCOderivative of carbon monoxide partial pressure
der_Tderivative of temperature
der_tHbderivative of total hemoglobin
der_cDPGderivative of diphosphoglicerate
der_FMetHbderivative of methemoglobin fraction
der_FHbFderivative of foethel hemoglobin fraction

Outputs

NameDescription
der_sO2COderivative of oxygen and carbon monoxide saturation

Physiolibrary.Media.Blood.setState_pTX Physiolibrary.Media.Blood.setState_pTX

Thermodynamic state

Information

Set thermodynamic state

Extends from (Return thermodynamic state as function of p, T and composition X or Xi).

Inputs

NameDescription
pPressure [Pa]
TTemperature [K]
X[:]Mass fractions [kg/kg]
velectric potential [V]

Outputs

NameDescription
stateThermodynamic state record

Physiolibrary.Media.Blood.setState_phX Physiolibrary.Media.Blood.setState_phX

Thermodynamic state

Information

Set thermodynamic state based on constant heat capacity

Extends from (Return thermodynamic state as function of p, h and composition X or Xi).

Inputs

NameDescription
pPressure [Pa]
hSpecific enthalpy [J/kg]
X[:]Mass fractions [kg/kg]
velectric potential [V]

Outputs

NameDescription
stateThermodynamic state record

Physiolibrary.Media.Blood.density Physiolibrary.Media.Blood.density

Density

Information

constant density

Extends from (Return density).

Inputs

NameDescription
stateThermodynamic state record

Outputs

NameDescription
dDensity [kg/m3]

Physiolibrary.Media.Blood.plasmaDensity

Density of blood plasma

Information

constant density

Extends from GetDensity.

Inputs

NameDescription
state 

Outputs

NameDescription
d[kg/m3]

Physiolibrary.Media.Blood.specificHeatCapacityCp Physiolibrary.Media.Blood.specificHeatCapacityCp

Specific heat capacityReturn specific heat capacity at constant pressure

Information

Constant specific heat capacity

Extends from (Return specific heat capacity at constant pressure).

Inputs

NameDescription
stateThermodynamic state record

Outputs

NameDescription
cpSpecific heat capacity at constant pressure [J/(kg.K)]

Physiolibrary.Media.Blood.temperature Physiolibrary.Media.Blood.temperature

Temperature

Information

Temperature

Extends from (Return temperature).

Inputs

NameDescription
stateThermodynamic state record

Outputs

NameDescription
TTemperature [K]

Physiolibrary.Media.Blood.pressure Physiolibrary.Media.Blood.pressure

Pressure

Information

Pressure

Extends from (Return pressure).

Inputs

NameDescription
stateThermodynamic state record

Outputs

NameDescription
pPressure [Pa]

Physiolibrary.Media.Blood.tO2

Total oxygen in blood

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.sO2

Oxygen saturation on effective hemoglobin

Information

Extends from GetFraction.

Inputs

NameDescription
state 

Outputs

NameDescription
F[1]

Physiolibrary.Media.Blood.tCO2

Total carbon dioxide in blood

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.tCO

Total carbon monoxide in blood

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.tHb

Total hemoglobine in blood

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.FMetHb

Methemoglobine fraction

Information

Extends from GetFraction.

Inputs

NameDescription
state 

Outputs

NameDescription
F[1]

Physiolibrary.Media.Blood.FHbF

Foetalhemoglobine fraction

Information

Extends from GetFraction.

Inputs

NameDescription
state 

Outputs

NameDescription
F[1]

Physiolibrary.Media.Blood.ctHb_ery

Total hemoglobine in erythrocytes

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.tAlb

Total albumine in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.tGlb

Total globulin in blood plasma [g/L]

Information

Extends from GetMassConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
R[kg/m3]

Physiolibrary.Media.Blood.tPO4

Total anorganic phosphates in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.cDPG

Total diphosphoglycerate in erythrocytes

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.SID

Strong ion difference of blood

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.glucose

Total glucose in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.lactate

Total lactate in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.urea

Total urea in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.aminoAcids

Total amino acids in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.lipids

Total faty acids in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.ketoAcids

Total ketoacids in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.epinephrine

Epinephrine in blood plasma

Information

Extends from GetMassConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
R[kg/m3]

Physiolibrary.Media.Blood.norepinephrine

Norepinephrine in blood plasma

Information

Extends from GetMassConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
R[kg/m3]

Physiolibrary.Media.Blood.vasopressin

Vasopressin in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.insulin

Insulin in blood plasma

Information

Extends from GetActivity.

Inputs

NameDescription
state 

Outputs

NameDescription
A[U/m3]

Physiolibrary.Media.Blood.glucagon

Glucagon in blood plasma

Information

Extends from GetMassConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
R[kg/m3]

Physiolibrary.Media.Blood.thyrotropin

Thyrotropin in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.thyroxine

Thyroxine in blood plasma

Information

Extends from GetMassConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
R[kg/m3]

Physiolibrary.Media.Blood.leptin

Leptin in blood plasma

Information

Extends from GetMassConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
R[kg/m3]

Physiolibrary.Media.Blood.desglymidodrine

Desglymidodrine in blood plasma

Information

Extends from GetMassConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
R[kg/m3]

Physiolibrary.Media.Blood.angiotensin2

Angiotensin2 in blood plasma

Information

Extends from GetMassConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
R[kg/m3]

Physiolibrary.Media.Blood.alphaBlockers

Alpha blockers effect

Information

Extends from GetExtraProperty.

Inputs

NameDescription
C[nC]Extra properties values

Outputs

NameDescription
e 

Physiolibrary.Media.Blood.betaBlockers

Beta blockers effect

Information

Extends from GetExtraProperty.

Inputs

NameDescription
C[nC]Extra properties values

Outputs

NameDescription
e 

Physiolibrary.Media.Blood.anesthesiaVascularConductance

Anesthesia vascular conductance effect

Information

Extends from GetExtraProperty.

Inputs

NameDescription
C[nC]Extra properties values

Outputs

NameDescription
e 

Physiolibrary.Media.Blood.aldosterone

Aldosterone in blood plasma

Information

Extends from GetConcentration.

Inputs

NameDescription
state 

Outputs

NameDescription
C[mol/m3]

Physiolibrary.Media.Blood.renin

Renin PRA in blood plasma

Information

Extends from GetActivity.

Inputs

NameDescription
state 

Outputs

NameDescription
A[ng/(ml.h)]

Physiolibrary.Media.Blood.plasmacrit

Blood plasmacrit [mL/mL]

Information

Extends from GetFraction.

Inputs

NameDescription
state 

Outputs

NameDescription
F[1]

Physiolibrary.Media.Blood.hematocrit

Blood hematocrit [mL/mL]

Information

Extends from GetFraction.

Inputs

NameDescription
state 

Outputs

NameDescription
F[1]

Physiolibrary.Media.Blood.formedElementsDensity

Density of blood formed elements (erythrocytes, leukocytes and thrombocytes)

Information

constant density

Extends from GetDensity.

Inputs

NameDescription
state 

Outputs

NameDescription
d[kg/m3]

Physiolibrary.Media.Blood.formedElementsMassFractionWithoutOther

Blood hematocrit without unknown substances in formed elements [kg/kg]

Information

Extends from formedElementsMassFraction (Blood hematocrit [kg/kg]).

Inputs

NameDescription
state 

Outputs

NameDescription
F[1]

Physiolibrary.Media.Blood.plasmaMassFractionWithoutOther

Blood plasmacrit without unknown substances in blood plasma [kg/kg]

Information

Extends from plasmaMassFraction (Blood plasmacrit [kg/kg]).

Inputs

NameDescription
state 

Outputs

NameDescription
F[1]
Automatically generated Wed Oct 11 14:54:18 2023.