Physiolibrary

Physiolibrary is a free open-source Modelica library designed for modeling human physiology. This library contains basic physical laws governing human physiology, usable for cardiovascular circulation, metabolic processes, nutrient distribution, thermoregulation, gases transport, electrolyte regulation, water distribution, hormonal regulation and pharmacological regulation.

Library description

Our laboratory have a long tradition building physiological libraries, starting with Physiolibrary in Matlab/Simulink environment. The origin of this Modelica Physiolibrary was in the first version of our HumMod Golem Edition model implementation, where it was called HumMod.Library. As the successors of Guyton's Medical Physiology School write, the original HumMod model is “The best, most complete, mathematical model of human physiology ever created”. In cooperation with this group we are now developing together the new complex integrative model of physiology called Physiomodel based on Physiolibrary and HumMod.

We are also developing many types of smaller physiological models for use in medical education, so it was essential to separate this library from our Modelica model implementations. Our Physiolibrary contains only carefully-chosen elementary physiological laws, which are the basis of more complex physiological processes. For example from only three type of blocks (ChemicalReaction, Substance and MolarConservationMass) it is possible to compose the allosteric transitions or the Michaelis-Menten equation.

Library contains also the icons for higher level (HumMod) subsystem implementations:

screenshot

Last release of OpenModelica has already integrated Physiolibrary between System Libraries.

Download last version of Physiolibrary.

Additional materials

Presentations & Publications

Awards

  • 1st price, Modelica Free Library Award, 10th International Modelica Conference, March 12, 2014, Lund, Sweden (ceremonial photo)
  • 1st price, Modelica Free Library Award, 11th International Modelica Conference, September 21-23, 2015, Paris, France

License (BSD)

Copyright (c) 2008-2015, Marek Mateják, Charles University in Prague
All rights reserved.

Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met:

  • Redistributions of source code must retain the above copyright notice, this list of conditions and the following disclaimer.
  • Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution.
  • Neither the name of the copyright holder nor the names of its contributors may be used to endorse or promote products derived from this software without specific prior written permission.
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