Physiolibrary

Physiolibrary is a free open-source Modelica library designed for modeling human physiology. This library contains basic physical laws governing human physiology, usable for cardiovascular circulation, metabolic processes, nutrient distribution, thermoregulation, gases transport, electrolyte regulation, water distribution, hormonal regulation and pharmacological regulation.

Library description

Our laboratory have a long tradition building physiological libraries, starting with Physiolibrary in Matlab/Simulink environment. The origin of this Modelica Physiolibrary was in the first version of our HumMod Golem Edition model implementation, where it was called HumMod.Library. As the successors of Guyton's Medical Physiology School write, the original HumMod model is “The best, most complete, mathematical model of human physiology ever created”. In cooperation with this group we are now developing together the new complex integrative model of physiology called Physiomodel based on Physiolibrary and HumMod.

We are also developing many types of smaller physiological models for use in medical education, so it was essential to separate this library from our Modelica model implementations. Our Physiolibrary contains only carefully-chosen elementary physiological laws, which are the basis of more complex physiological processes. For example from only three type of blocks (ChemicalReaction, Substance and MolarConservationMass) it is possible to compose the allosteric transitions or the Michaelis-Menten equation.

Library contains also the icons for higher level (HumMod) subsystem implementations:

screenshot

Last release of OpenModelica has already integrated Physiolibrary between System Libraries.

Download last version of Physiolibrary.

Additional materials

Generated documentation of Physiolibrary 2.3.1
Short presentation of Physiolibrary 2.3
Chemical library
Physiomodel - model of human physiology
Physiovalues - Project of web application to compute, store and provide values of parameters of physiological models.

Presentations & Publications

Marek Mateják, Martin Tribula, Filip Ježek, Jiří Kofránek: Free Modelica library of chemical and electrochemical processes, In Conference Proceeding, 11th International Modelica Conference, Septamber 21, 2015, Paris, France
Marek Mateják, Tomáš Kulhánek, Jan Šilar, Pavol Privitzer, Filip Ježek, Jiří Kofránek: Physiolibrary - Modelica library for Physiology, In Conference Proceeding, 10th International Modelica Conference, March 12, 2014, Lund, Sweden, (DOI:10.3384/ECP14096499)
Marek Mateják: Physiology in Modelica, MEFANET Journal 2014; 2(1); ISSN:1805-9171. Available at WWW: http://mj.mefanet.cz/mj-03140307
Marek Mateják: Physiolibrary - fyziológia v Modelice, Medsoft 2014, March 26, 2014, ISSN:1803-8115, ISBN:978-80-86742-38-0, pg.165-172
T. Kulhánek, J. Kofránek, and M. Mateják: Modeling of short-term mechanism of arterial pressure control in the cardiovascular system: Object-oriented and acausal approach, Computers in Biology and Medicine, vol. 54, pp. 137-144, 11/1/ 2014.
Kulhánek T, Tribula M, Kofránek J, Mateják M: Simple models of the cardiovascular system for educational and research purposes. MEFANET Journal 2014; 2(2); ISSN:1805-9171. Available at WWW: http://mj.mefanet.cz/mj-04140914.
Marek Mateják, Tomáš Kulhánek, Stanislav Matoušek: Adair-based hemoglobin equilibrium with oxygen, carbon dioxide and hydrogen ion activity. Scandinavian Journal of Clinical and Laboratory Investigation, vol. 75, pp. 113-120, 2015/02/17 2015. (DOI:10.3109/00365513.2014.984320)

Awards

1st price, Modelica Free Library Award, 10th International Modelica Conference, March 12, 2014, Lund, Sweden (ceremonial photo)
1st price, Modelica Free Library Award, 11th International Modelica Conference, September 21-23, 2015, Paris, France

License (BSD)

Redistribution and use in source and binary forms, with or without modification, are permitted provided that the following conditions are met:

Redistributions of source code must retain the above copyright notice, this list of conditions and the following disclaimer.
Redistributions in binary form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution.
Neither the name of the copyright holder nor the names of its contributors may be used to endorse or promote products derived from this software without specific prior written permission.

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